Sinergija KBT i tDCS terapije za liječenje depresije i anksioznosti.
- Damir Rovis
- May 24
- 2 min read
Više recentnih istraživanja potvrđuju sinergijski učinak KBT (kognitivno-bihevioralna terapija) i tDCS (transkranijalna stimulacija istosmjernom strujom) liječenja depresije i dugotrajnog smanjenja simptoma bolesti (anksioznost, kvaliteta sna, bolje raspoloženje) kroz više tjednu terapiju. Neurostimulacija frontalnog korteksa povećava neuroplastičost i kognitivnu kontrolu pojačavajući time učinak KBT.
Delayed Effects of tDCS Combined with Cognitive Behavioral Therapy in Major Depression: A Randomized, Double-Blind Pilot Trial
Psychological Neuroscience Laboratory, Centro de Investigação em Psicologia (CIPsi), Department of Basic Psychology, School of Psychology, University of Minho, 4710-057 Braga, Portugal
Brain Sci. 2025, 15(5), 444; https://doi.org/10.3390/brainsci15050444
Conclusions
This pilot study suggests that the integration of transcranial direct current stimulation (tDCS) and cognitive behavioral therapy (CBT) may improve treatment efficacy for patients with MDD, especially in the long-term relief of symptoms. While both groups were able to reap benefits from CBT, those who were given active tDCS were able to achieve even greater and longer-lasting reductions in depressive symptoms. Most notably, the benefits extended beyond depression, encompassing reduced anxiety, improved sleep, greater life satisfaction, and an enhanced sense of well-being, suggesting that the combined treatment may trigger a broader and progressively accelerating therapeutic effect.
These findings support the theory that neuromodulation of the dorsolateral prefrontal cortex enhances neuroplasticity and cognitive control, thereby amplifying the effects of CBT. The effects that were noted during follow-up assessments highlight the need to consider longer time frames, particularly in reference to measuring the effectiveness of multi-pronged therapy approaches.
Comparing efficacy of cognitive behavioral therapy, rtms tdcs for reducing depressive symptoms and cognitive deficits in major depression
Results: The results showed that tDCS, TMS, and cBT significantly reduced depression symptoms. Only the Hamilton test showed a significant group difference, favoring cBT over the drug group. tDCS outperformed in working memory and cognitive flexibility, while cBT showed improvements in attention and concentration. Results persisted after one month.
Conclusion:
While CBT was more effective for reducing depression symptoms tDCS was more effective for improving cognitive functions.
Efficacy of CBT, intensified tDCS and their combination for reducing clinical symptoms and improving quality of life in social anxiety disorder with comorbid depression: a randomized controlled trial
BMC Psychiatry volume 25, Article number: 438 (2025)
Results
SAD symptoms significantly decreased after intervention and follow-up in all groups, with no significant differences between them. However, CBT + tDCS resulted in a numerically larger symptom reduction, significantly exceeding CBT + sham tDCS on the fear scale. Depressive states and trait worry significantly improved in all groups post-intervention and at the 3-month follow-up, with no between-group differences. Quality of life (total scores, physical, and psychological domains) significantly improved after the and at the 3-month follow-up only in the CBT + tDCS and tDCS-alone groups with no between-group differences.
Conclusion
Psychotherapeutic interventions with CBT, intensified tDCS targeting the prefrontal cortex, and the combined CBT-tDCS are effective for alleviating primary and secondary clinical symptoms in individuals with SAD. The combined CBT-tDCS intervention showed superior efficacy in reducing the primary symptoms of SAD.
Comments